'SPDY,' High-Res Opera 12.10 Arrives

Opera has updated its flagship desktop web browser to version 12.10, which offers several speed improvements, new goodies for web developers and better integration with Apple’s latest Retina screen laptops.

To grab a copy of Opera 12.10 beta for Windows, Mac or Linux, head on over to the Opera download page.

Among Opera 12.10′s standout features is baked-in support for the new SPDY network standard, which offers faster, more secure connections to websites that support it, including big names like Gmail and Twitter.

Opera 12.10 now supports the latest Web Sockets implementation, which fixes the security flaws that previously forced Opera to remove Web Sockets support. Web Sockets are back on by default. Another web standards improvement in Opera 12.10 is support for more “unprefixed” CSS rules, including transitions, transforms, gradients, and animations, all of which will now work without the -o- prefix.

Web developers starting to play with the new CSS Flexible Box Layout Module syntax can now test layouts in Opera 12.10. Check out CSS guru Chris Coyer’s earlier rundown of what’s changed recently with Flexbox.

There’s good news for Mac users in this release — Opera 12.10 is the first to support Apple’s high-res display, making it well worth the update if you’ve got one of the new Retina MacBook Pros. Other Mac improvements include support for new features in OS X Mountain Lion, like the new Notification Center and the built-in content sharing through any social network accounts you’ve set up.

Windows 8 users will be happy to know that basic touch support now works in Windows 8. It’s nowhere near as nice as what you’ll find in IE 10 or Firefox, but it’s a start.

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UK PM warns of witch-hunt against gays in pedophile scandal

LONDON (Reuters) – British Prime Minister David Cameron warned on Thursday that speculation about the identity of an unidentified member of his ruling Conservative party accused of sexually abusing children could turn into a witch-hunt against gay people.

Cameron, who leads a troubled two-party coalition, ordered an investigation this week after a victim of child sexual abuse in Wales said a prominent Conservative political figure had abused him during the 1970s.

The claims, which follow the unmasking of late BBC star presenter Jimmy Savile as one of Britain’s most prolific sex offenders, have stoked concern that a powerful pedophile ring may have operated in Britain in the 1970s and 1980s.

“I have heard all sorts of names bandied around and what then tends to happen is of course that everyone then sits around and speculates about people, some of whom are alive, some of whom are dead,” Cameron said during an ITV television interview.

“It is very important that anyone who has got any information about any pedophile no matter how high up in the country go to the police,” he said.

Britain’s interior minister warned lawmakers this week that if they named suspected child abusers in parliament they risked jeopardizing future trials.

MPs benefit from “parliamentary privilege” – meaning they can speak inside parliament freely without fear of legal action on a host of legally sensitive issues that might otherwise attract lawsuits.

Reports of child abuse have provoked fevered speculation on the Internet about the identity of the Conservative figure from the era of Margaret Thatcher, prime minister from 1979 to 1990.

When the ITV interviewer passed Cameron a piece of paper with the names of people identified on the Internet as being alleged child abusers, Cameron said:

“There is a danger if we are not careful that this could turn into a sort of witch-hunt particularly against people who are gay.”

“I am worried about the sort of thing you are doing right now – giving me a list of names you have taken off the Internet,” Cameron said.

The BBC aired a program last week in which Steven Messham, one of hundreds of victims of sexual abuse at children’s care homes in Wales over two decades, said he had been sexually abused by a prominent Conservative political figure.

However, the BBC reporter said he could not name the figure because there was “simply not enough evidence to name names”.

(Reporting by Guy Faulconbridge; Editing by Andrew Osborn)

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Well: The Presidential Health Quiz

Whether it’s George Washington’s teeth or Bill Clinton’s former hamburger habit, Americans have always been fascinated by the health of the president and presidential candidates.

With help from the Web site DoctorZebra, which has compiled an exhaustive list of the medical history of American presidents, we’ve created an Election Day quiz to test your knowledge of presidential fitness and health.

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DealBook: On Wall Street, Time to Mend Fences With Obama

Del Frisco’s, an expensive steakhouse with floor-to-ceiling windows overlooking the Boston harbor, was a festive scene on Tuesday evening. The hedge fund billionaires Steven A. Cohen, Paul Singer and Daniel Loeb were among the titans of finance there dining among the gray velvet banquettes before heading several blocks away to what they hoped would be a victory party for their presidential candidate, Mitt Romney.

The next morning was a cold, sobering one for these executives.

Few industries have made such a one-sided bet as Wall Street did in opposing President Obama and supporting his Republican rival. The top five sources of contributions to Mr. Romney, a former top private equity executive, were big banks like Goldman Sachs and JPMorgan Chase, according to the Center for Responsive Politics. Wealthy financiers — led by hedge fund investors — were the biggest group of givers to the main “super PAC” backing Mr. Romney, providing almost $33 million, and gave generously to outside groups in races around the country.

On Wednesday, Mr. Loeb, who had supported Mr. Obama in 2008, was sanguine. “You win some, you lose some,” he said in an interview. “We can all disagree. I have friends and we have spirited discussions. Sure, I am not getting invited to the White House anytime soon, but as citizens of the country we are all friendly.”

Wall Street, however, now has to come to terms with an administration it has vilified. What Washington does next will be critically important for the industry, as regulatory agencies work to put their final stamp on financial regulations and as tax increases and spending cuts are set to take effect in the new year unless a deal to avert them is reached. To not have a friend in the White House at this time is one thing, but to have an enemy is quite another.

“Wall Street is now going to have to figure out how to make this relationship work,” said Glenn Schorr, an analyst who follows the big banks for the investment bank Nomura. “It’s not impossible, but it’s not the starting point they had hoped for.”

Traditionally, the financial industry has tended to support Republican candidates, but, being pragmatic about power, has also donated to Democrats. That script got a rewrite in 2008, when many on Wall Street supported Mr. Obama as an intelligent leader for a country reeling from the financial crisis. Goldman employees were the leading source of campaign donations for Mr. Obama, who reaped far more contributions — roughly $16 million — from Wall Street than did his opponent, John McCain.

The love affair between Wall Street and Mr. Obama soured soon after he took office and championed an overhaul in financial regulations that became the Dodd-Frank Act.

Some financial executives complained that in meetings with the president, they found him uninterested and disengaged, while others on Wall Street never forgave Mr. Obama for calling them “fat cats.”

The disillusionment with the president spawned reams of critical commentary from Wall Street executives.

“So long as our leaders tell us that we must trust them to regulate and redistribute our way back to prosperity, we will not break out of this economic quagmire,” Mr. Loeb wrote in one letter to his investors.

The rhetoric at times became extreme, like the time Steven A. Schwarzman, co-founder of the private equity firm Blackstone Group, compared a tax proposal to “when Hitler invaded Poland in 1939.” (Mr. Schwarzman later apologized for the remark.)

Mr. Loeb was not alone in switching allegiances in the recent presidential race. Hedge fund executives like Leon Cooperman who had supported Mr. Obama in 2008 were big backers of Mr. Romney in 2012. And Wall Street chieftains like Jamie Dimon of JPMorgan Chase and Lloyd C. Blankfein of Goldman Sachs, who have publicly been Democrats in the past, kept a low profile during this election. But their firms’ employees gave money to Mr. Romney in waves.

Starting over with the Obama White House will not be easy. One senior Wall Street lawyer who spoke on condition of anonymity said Wall Street “made a bad mistake” in pushing so hard for Mr. Romney. “They are going to pay a price,” he said. “It will soften over time, but there will be a price.”

Mr. Obama is not without supporters on Wall Street. Prominent executives like Hamilton James of Blackstone, and Robert Wolf, a former top banker at UBS, were in Chicago on Tuesday night, celebrating with the president.

“What we learned is the people on Wall Street have one vote just like everyone else,” Mr. Wolf said. Still, while the support Wall Street gave Mr. Romney is undeniable, Mr. Wolf said, “Mr. Obama wants a healthy private sector, and that includes Wall Street.

“If you look at fiscal reform, infrastructure, immigration and education, they are all bipartisan issues and are more aligned than some people make it seem.”

Reshma Saujani, a former hedge fund lawyer who was among Mr. Obama’s top bundlers this year and is planning to run for city office next year, agreed.

“Most people in the financial services sector are social liberals who support gay marriage and believe in a woman’s right to choose, so I think many of them will swing back to Democrats in the future,” she said.

---

This post has been revised to reflect the following correction:

Correction: November 8, 2012

An earlier version of this article misidentified Reshma Saujani as a male.

A version of this article appeared in print on 11/08/2012, on page B1 of the NewYork edition with the headline: On Wall Street, Time to Mend Fences With Obama.

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Questions linger following Obama's reelection victory

President Obama celebrates his victory Wednesday, and plans a meeting with Republican presidential candidate Mitt Romney.

President Barack Obama has won re-election. The Republican Party faces a reckoning about its identity. In Florida, however, the election goes on.

The state whose dysfunctional voting methods traumatized the nation 12 years ago, is still up in the air.  The state was supposed to have been a major presidential battleground, but the morning after election day, it was still a question mark.

Instead of butterfly ballots and hanging chads, the problem appears to have been caused by a long ballot, high turnout and some mechanical failures.

Even the president, in his victory speech in Chicago, acknowledged the problem:

“I want to thank every American who participated in this election, whether you voted for the very first time or waited in line for a very long time--by the way, we have to fix that.”

PHOTOS: America goes to the polls

On Wednesday morning, all precincts in Florida had finished reporting, and the totals gave an edge of more than 46,000 votes to Obama, about half of one percent.  Even without Florida’s 29 electoral votes, Obama accrued far more than the 270 he needed to secure re-election. (Without Florida, the total was 303 electoral votes for the president to GOP challenger Mitt Romney’s 206.)

The worst of the problems occurred in Miami-Dade, the state's largest county. Long lines began before the polls opened Tuesday and never let up; when the election was called for Obama, people were still standing in line at dozens of precincts. The Miami Herald reported that the last Miami-Dade voter finished just after 1 a.m.

A number of counties had not yet counted their absentee ballots. In Miami-Dade, elections workers still had to count 20,000 absentees. In Pinellas County, which includes St. Petersburg, there were about 9,000 absentees yet to be counted. Elections officials said it would be Wednesday afternoon before the results would be final.

John Card, an attorney heading the Elections Protections monitoring effort in Miami-Dade on Tuesday, said voting actually went smoothly in much of the county. But in some precincts, he said, it was a "debacle."

Voters faced a ballot filled with complicated constitutional amendments and local issues. For some, it was 12 pages long. In some crowded precincts, scanners malfunctioned. In others, poll workers were confused about the state's new rules on address changes, Card said. Some voters were told they were ineligibleto vote, others may have been purged from rolls improperly.

LIVE: Presidential election results

"I do think they were a little overwhelmed in some places," he said. "A number of people got frustrated and left," said Card, whose organization is a coalition of advocacy groups. "The system played out in a way that denied them the right to vote."

The president’s victory may not have packed the same emotional punch as his historic 2008 win as the first African-American to win the presidency. But early Wednesday morning, as he stood on a Chicago stage to address the nation, he seemed to reconjure the conciliatory, high-minded politician the country first got to know four years ago.

That man—with the inspiring speeches and the ability to make Americans believe in their better angels--had sometimes disappeared under the fatigue, stress or just plain aversion to the brutal  campaign process.

The president attempted to set a peaceable tone for a country inflamed by hot partisan sentiment, stoked by the stunning amounts of money that had flowed unimpeded into the race.

Though his first term accomplishments, such as health care reform and a stimulus bill that most economists say helped stave off a second Great Depression, were accomplished with almost no Republican support, he vowed to be a better bi-partisan in his second term.

“I am looking forward to reaching out and working with leaders of both parties to meet the challenges we can only solve together:  reducing our deficit;  reforming our tax code; fixing our immigration system; freeing ourselves from foreign oil.”

PHOTOS: President Obama’s past

He also said he planned to meet with Romney “to talk about where we can work together to move this country forward.”

Before the president spoke, Romney, 65, the former Massachusetts governor, had conceded the election in a gracious but wistful speech before downcast supporters in Boston.

“I so wish that I’d been able to fulfill your hopes to consider as a course in a different direction,” Romney said in his brief speech, “but the nation chose another leader and so Ann and I join with you to earnestly pray for him and this great nation.” 

Meanwhile, in Washington, Republicans began to grapple with the party’s future. The party kept control of the House, but despite its hopes for much of the election cycle did not wrest control of the Senate from Democrats. Montana incumbent Jon Tester was declared the victor over Republican Denny Rehberg Wednesday morning, saving for Democrats one of Republicans’ biggest pick-up hopes.

With Romney vanquished, the party’s putative leaders are its top legislators, House Speaker John Boehner, Senate Minority Leader Mitch McConnell and House Majority Leader Eric Cantor.

But Romney’s running mate, Rep. Paul Ryan, often touted as the ideological leader of the party’s conservative wing, will have solidified his importance as the GOP grapples with its ideological future, as well as with the demographic changes that contributed to its failure to recapture the White House.

PHOTOS: Mitt Romney’s past

In a statement released after midnight Tuesday, Boehner congratulated the president, noted that the Republicans have maintained their majority in the House of Representatives, and cautioned the president.

“If there is a mandate,” said Boehner, “it is a mandate for both parties to find common ground and take steps together to help our economy grow and create jobs, which is critical to solving our debt.”

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Joseph.tanfani@latimes.com

Twitter: @jtanfani

Robin.abcarian@latimes.com

Twitter: @robinabcarian

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SparkTruck's Surprise Lesson: Using Design Skills to Build Kids' Character

When Eugene Korsunskiy and seven of his fellow students from Stanford University’s d.school set out to tour the nation in a brightly painted truck full of laser cutters and rapid prototyping machines, they thought they were bringing a chance to play with high-tech maker tools to school kids who hadn’t had one yet.

And they were: SparkTruck, the educational make-mobile, made 73 stops this summer, treating 2,679 elementary and middle school students to hands-on workshops covering the basics of electrical engineering and digital fabrication, and giving a chance to make cool stuff in the process, like small robotic creatures and laser-cut rubber stamps.

But as the summer progressed, the SparkTruck team learned an unlikely lesson. The most rewarding part of the trip wasn’t introducing the kids to new technologies. Instead it was something far more basic: watching them struggle with design problems.

Only one of the SparkTruck team had training in education. But when the group planned its workshops, Korsunskiy explained, they knew they wanted to emphasize the same skills and processes they’d learned in design school. “Somewhere in each activity, we wanted the kids to get stuck, physically or mentally,” he said.

The point wasn’t to torture children, but to force them to work through an open-ended problem on their own.

Some teachers were skeptical. “One teacher told us, ‘My students are so conditioned to thinking that I’ll give them the right answers,’” Korsunskiy said. She didn’t think the group’s approach, which Korsunskiy summarized as “giving [kids] the space but not giving them the answers,” would work.

Sure enough, the SparkTruck team noticed kids’ resistance. Presented with a design problem, students would get stuck — and as the teacher predicted, they would come to the facilitators and ask, ‘How do I do this?’ They would beg, plead, and get frustrated. The SparkTruck team would withhold answers, instead asking a kid with, for example, no idea how to keep her robot from falling over, ‘How do you think it cold be done?’

Eventually, the hard-nosed approach paid off. “After an interaction like that, you see a gear shift in [a kid's] head,” said Korsunskiy. “Once you make it clear that you’re not there to provide the answer, they completely rise to the challenge.”

Unwittingly, the team had stumbled into a big problem — and a gathering cultural debate. According to social scientists (and the journalists who popularize their work), American children are said to be weenies, much more helpless and less resourceful than their age-matched peers in other countries. In educational settings, American kids are worryingly lacking in the faculty known as “grit,” the one that allows people to power through difficult problems, absorbing and learning from setbacks rather than giving up.

The point isn’t that young Americans are destined to be this way, but that somehow, amid all our prosperity, we’ve stopped giving kids the conditions they need to become self-sufficient.

Could hands-on, design-inspired education help? Korsunskiy and his team think so. Design lessons, Korsunisky noted, are based around creative problem-solving. They’re not about memorizing right answers but about developing critical thinking skills, learning to work through problems in a repeated process of brainstorming, testing solutions, and going back to the drawing board. In short, this kind of education builds the very skills of perseverance and intellectual independence that parents, teachers, and social critics say that American children have in short supply.

For Korsunskiy, watching students hit a wall — and then figure out a way over (or around) it — was the most rewarding part of the SparkTruck experience.

Students of today aren’t necessarily going to need to know how to operate, say, a CNC router, he noted. But if this generation is to succeed, it will absolutely need to know “how to approach hairy, multi-variate problems without freaking out” — he name-checked climate change and the obesity epidemic — i.e., to be able to leverage the skills and mindset that a shop-class environment can instill.

As the summer went on, the SparkTruck team shifted focus, beginning to feel more like emissaries for that problem-solving mindset and design process, rather than for the bright, shiny machines in the back.

Which isn’t to say that the machines aren’t helpful for grabbing the attention of students — and educators too.

“When we say we have laser cutters and 3-D printers on board, that makes it way more exciting to principals and teachers,” Korsunskiy said. “We sneak the thing about creativity in the back door.”

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“Dad’s Army” star Clive Dunn dies aged 92

LONDON (Reuters) – British actor Clive Dunn, best known as a bumbling old butcher in the popular World War Two sitcom “Dad’s Army”, has died, his agent said on Wednesday.

Dunn passed away on Tuesday, Peter Charlesworth said, adding that he believed the actor died in Portugal where he has lived for many years. He was 92.

As Lance-Corporal Jones in Dad’s Army – a hit television series in the 1960s and 1970s about a group of local volunteer members of the Home Guard – Dunn was famous for catchphrases such as “Don’t panic!” and “They don’t like it up ‘em.”

He also had a No. 1 hit song with “Grandad” in 1971, which he performed several times on TV music show “Top of the Pops”.

Dunn was born in London in 1920 and enrolled in an acting academy after leaving school.

He played several small roles in films in the 1930s before serving in the army in World War Two, ending up in prisoner-of-war and labor camps for four years.

After the war he worked in music halls before enjoying success as Jones in Dad’s Army.

Underlining his ability to play characters far older than his real age, he followed Dad’s Army with a five-year run in children’s comedy series “Grandad” as an elderly caretaker.

According to the BBC, he is survived by his wife Priscilla Morgan and two daughters, Jessica and Polly.

(Reporting by Mike Collett-White, editing by Paul Casciato)

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Alarm Over India’s Dengue Fever Epidemic

Enrico Fabian for The New York Times

A man at the Yamuna River, an ideal breeding ground for mosquitoes. Filthy standing water abounds in New Delhi. More Photos »

NEW DELHI — An epidemic of dengue fever in India is fostering a growing sense of alarm even as government officials here have publicly refused to acknowledge the scope of a problem that experts say is threatening hundreds of millions of people, not just in India but around the world.

India has become the focal point for a mosquito-borne plague that is sweeping the globe. Reported in just a handful of countries in the 1950s, dengue (pronounced DEN-gay) is now endemic in half the world’s nations.

“The global dengue problem is far worse than most people know, and it keeps getting worse,” said Dr. Raman Velayudhan, the World Health Organization’s lead dengue coordinator.

The tropical disease, though life-threatening for a tiny fraction of those infected, can be extremely painful. Growing numbers of Western tourists are returning from warm-weather vacations with the disease, which has reached the shores of the United States and Europe. Last month, health officials in Miami announced a case of locally acquired dengue infection.

Here in India’s capital, where areas of standing water contribute to the epidemic’s growth, hospitals are overrun and feverish patients are sharing beds and languishing in hallways. At Kalawati Saran Hospital, a pediatric facility, a large crowd of relatives lay on mats and blankets under the shade of a huge banyan tree outside the hospital entrance recently.

Among them was Neelam, who said her two grandchildren were deathly ill inside. Eight-year-old Sneha got the disease first, followed by Tanya, 7, she said. The girls’ parents treated them at home but then Sneha’s temperature rose to 104 degrees, a rash spread across her legs and shoulders, and her pain grew unbearable.

“Sneha has been given five liters of blood,” said Neelam, who has one name. “It is terrible.”

Officials say that 30,002 people in India had been sickened with dengue fever through October, a 59 percent jump from the 18,860 recorded for all of 2011. But the real number of Indians who get dengue fever annually is in the millions, several experts said.

“I’d conservatively estimate that there are 37 million dengue infections occurring every year in India, and maybe 227,500 hospitalizations,” said Dr. Scott Halstead, a tropical disease expert focused on dengue research.

A senior Indian government health official, who agreed to speak about the matter only on the condition of anonymity, acknowledged that official figures represent a mere sliver of dengue’s actual toll. The government only counts cases of dengue that come from public hospitals and that have been confirmed by laboratories, the official said. Such a census, “which was deliberated at the highest levels,” is a small subset that is nonetheless informative and comparable from one year to the next, he said.

“There is no denying that the actual number of cases would be much, much higher,” the official said. “Our interest has not been to arrive at an exact figure.”

The problem with that policy, said Dr. Manish Kakkar, a specialist at the Public Health Foundation of India, is that India’s “massive underreporting of cases” has contributed to the disease’s spread. Experts from around the world said that India’s failure to construct an adequate dengue surveillance system has impeded awareness of the illness’s vast reach, discouraged efforts to clean up the sources of the disease and slowed the search for a vaccine.

“When you look at the number of reported cases India has, it’s a joke,” said Dr. Harold S. Margolis, chief of the dengue branch at the Centers for Disease Control and Prevention in Atlanta.

Neighboring Sri Lanka, for instance, reported nearly three times as many dengue cases as India through August, according to the World Health Organization, even though India’s population is 60 times larger.

Hari Kumar contributed reporting.

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Mothers from Central America search for missing kin in Mexico

SALTILLO, Mexico — The mothers knock on the doors of flophouses and morgues. They sift through pictures of prisoners and the dead. Clutching pictures of their own, some from long ago, they ask the same questions, over and over.

Have you seen him? Does she look familiar?

Occasionally, there is a reported sighting. More often, it's another shake of the head, a "Sorry, no." And with that, weariness stooping their shoulders and worry sagging their faces, they board their bus and move on to another town.

By last weekend, these mothers, wives and sisters of missing Central American migrants had already crossed some of Mexico's most dangerous territory in their two-bus caravan.

Following a route often used by migrants northward along the Gulf Coast to the U.S., they had entered the country in the south through Tabasco state. They traveled through Veracruz and Tamaulipas, sites recently of horrific massacres of Central Americans and others, stopping along the way to ask and search — against all the odds wishing for a happy ending.

By the time they finish what has become an annual mission organized by several migrant rights and church groups, they will have traveled to 23 cities and towns in 14 states in 19 days. A total of nearly 3,000 miles.

Aboard the buses, with the lived-in feel of ordered chaos, the women pass the time dozing, chatting, occasionally watching a movie.

Despite their pain, or perhaps because of it, they find friendship. The Nicaraguans share stories of their experiences during their country's civil war, telling of relatives killed or forced into armies; the Hondurans recount tales of their nation's utter, violent poverty that fuels one of the world's highest homicide rates and drives their children to seek lives elsewhere.

Emotions soar and fall. The women joke and tease one another and laugh. Then, suddenly, one remembers the son she is missing and breaks into sobs and another moves to her side to comfort her.

Another nine hours through hot, dusty cactus fields brought them here to Saltillo, the capital of Coahuila state, where the top leader of the notorious Zetas paramilitary cartel was slain by government forces last month. By all accounts, it is the Zetas who most routinely and viciously prey on the migrants, thousands of whom have gone missing in recent years — kidnapped, killed, pressed into involuntary labor by drug traffickers, or simply lost to poverty and desperation.

Dilma Pilar Escobar last heard from her daughter, Olga, in January 2010. Olga had taken off from their home in Progreso, Honduras, leaving behind five children, with the plan of reaching the United States. Like so many others, her idea was to earn a little money, make things a little easier for her mother and her children.

Now Escobar is raising her grandchildren, listening to their questions every night about when their mother might come home. She is running out of answers.

"I've looked in hospitals, in morgues," said Escobar, 55. "We see so much about what's happening in Mexico on TV. It puts a lot in your head."

Escobar was inspired to make the trip in part by a local radio program that attempts to help families with missing relatives.

"It gave me the push to come here," said the woman with dark, unsmiling eyes, grasping an 8-by-10 photo of Olga that hangs from her neck on a green cord.

In each city or town, the mothers stage a public event to make their presence known. A Mass. A march. Here in Saltillo, they converged on the downtown Plaza de Armas, the pale-blue-and-white that adorns all Central American flags fluttering in the breeze ahead of the slow march of mothers. They hung their photos of loved ones on clotheslines at the center of the square.

The women — about 40 on this year's caravan — sleep on cots in churches or in "migrant houses," shelters set up by a number of communities, where they also receive donated meals.

"We are facing a humanitarian tragedy," Tomas Gonzalez, a Franciscan friar who runs a shelter in Tabasco, told the women. "Mexico has become a cemetery for migrants."

In August 2010, 72 migrants from El Salvador, Honduras, Guatemala and a handful of other countries were slain execution-style, hands tied behind backs, shot once in the head, in Tamaulipas state, which borders Texas. Among the youngest was 15-year-old Yedmi Victoria Castro of El Salvador. The Zetas were presumed responsible. Dozens more bodies were found in the same region in the months that followed.

Not a week goes by, it seems, without fresh reports of hidden graves and unidentified dead. But the Mexican government has been slow to recognize the epidemic of missing persons, only this year moving to toughen legislation and expand the collection of DNA samples and other data.

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Why Blind Mole Rats Don't Get Cancer

By Ian Steadman, Wired UK

Blind mole rats don’t get cancer, and geneticists have worked out why: Their cells kill themselves with a poisonous protein when they multiply too much.

Mole rats, which live in underground burrows throughout Southern and Eastern Africa, and the Middle East, are fascinating creatures. The naked mole rat, in particular, is the only cold-blooded mammal known to man, doesn’t experience pain, and is also arguably the only mammal (along with the Damaraland mole rat) to demonstrate eusociality — that is, they live in large hierarchical communities with a queen and workers, like ants or bees.

They’re also cancer-proof, which was found in 2011 to be down to a gene that stops cancerous cells from forming. The same team thought that two other cancer-proof mole rat species might have similar genes, but instead it turns out that they do develop cancerous cells. It’s just that those cells are programmed to destroy themselves if they become dangerous.

The two species examined by the University of Rochester’s Vera Gorbunova and her team were the Judean Mountains blind mole rat (Spalax judaei) and the Golan Heights blind mole rat (Spalax golani), which live within small regions of Israel. The team took cells from the rodents and put them in a culture that would force them to multiply beyond what would happen within the animals’ bodies. For the first seven to 20 multiplications, things looked fine, but beyond 20 multiplications the cells started rapidly dying off.

Examining the cells as they died revealed that they had started to produce a protein, IFN-β, that caused them to undergo “massive necrotic cell death within three days”. In effect, once the cells had detected that they had multiplied beyond a certain point, they killed themselves.

It contrasts with the self-preservation method seen in the cells of naked mole rats, which have a hypersensitivity to overcrowding, which stops them from multiplying too much. In the Proceedings of the National Academy of Sciences, Gorbunova hypothesizes that the blind mole rats’ unique habitat — almost entirely underground — might mean that they “could perhaps afford to evolve a long lifespan, which includes developing efficient anti-cancer defences”. Blind mole rats have extremely long lifespans by rodent standards, often living beyond 20 years at a time.

The reasons why this is, though, are still all hypothetical, as the precise mechanism that triggers the production of the IFN-β is still unknown. The hope is that this research could eventually lead to new therapies for cancer in humans.

Source: Wired.co.uk

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